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This drug is an antiplatelet drug that inhibit blood clots in cerebrovascular disease, peripheral vascular disease and coronary artery disease. It is distributed by Sanofi-Aventis, Bristol-Myers Squibb, Sun Pharmaceutical, Intas Pharmaceutical and Ranbaxy Laboratories.
This drug is a pro-drug whose action is connected to adenosine diphosphate receptor on platelet cell membranes and this type of receptor is important in platelet aggregation and cross-linking of platelet by fibrin.
This drug is indicated for patients with acute coronary syndrome without ST-segment elevation, prevention of vascular ischemic events and myocardial infarction with ST elevation.
It is also used together with aspirin; to prevent thrombosis. Plavix is available in the market with 75 mg oral tablet. This drug has no platelet inhibiting effect and plasma concentrations are very low and below quantification limit 2 hours after initial dose. The active metabolite found on the drug has an elimination half-life of 8 hours and acts as disulfide bridge with platelet ADP receptor. 50% of the drugs are excreted in the urine and 46% are excreted in the feces 5 days after the dose.
The drug is rapidly absorbed after a meal and with peak plasma levels of 3 mg/L one hour after dosing.
Plavix is well-tolerated but not for everyone. The therapy should be individualized according to patient’s medical history. It is important to discuss with the health provider regarding the side effects patient can experienced. The doctor will be the one to discuss if you may need to discontinue taking the drug.
The effectiveness of the drug has been proven in patient’s who have suffered a heart attack or the being hospitalized because of heart related chest pains.
If you have other conditions related to bleeding, patient should not take this drug because it would increase the risk. It is important to tell the doctor if you got unexplained weakness, if you had stroke because it may be a sign of TTP; a rare life threatening situation. The reported side effects are: purplish spots, rash and diarrhea. . This drug is not recommended in patients taking phenytoin, heparin, fluvastation, tolbutamide, anistreplase, urokinase, enoxaparin and danaparoid. If you are taking the drugs mentioned, you may need dosage adjustments or special tests during the treatment.